10 Anti-Aging Supplements
A Science-Backed Longevity & Cellular Optimization Guide by Hackfitz
Aging is not just about wrinkles or reduced energy it’s a gradual decline in cellular function, mitochondrial efficiency, hormonal balance, and repair mechanisms. Modern biohacking focuses on slowing this decline by supporting the body at a cellular and molecular level.
At Hackfitz, we approach anti-aging as a biological optimization process, not a cosmetic fix. The supplements below are backed by research and commonly used in longevity protocols to enhance energy, resilience, and long-term health.
1. NAD IV (Nicotinamide Adenine Dinucleotide)
NAD is a critical coenzyme found in every cell of the body, essential for energy production and DNA repair. Levels decline significantly with age, contributing to fatigue, cognitive decline, and accelerated aging.
How it works
NAD fuels mitochondrial energy (ATP), activates longevity pathways such as sirtuins, and supports cellular repair. IV delivery bypasses digestion, providing higher bioavailability.
Key benefits
- Increased energy and mental clarity
- Enhanced cellular repair
- Improved metabolic and immune resilience
- Slowing of biological aging markers
Typical protocol
2. CoQ10 (Coenzyme Q10) - Oral or IV
How it works
Key benefits
- Cardiovascular and brain health support
- Improved cellular energy
- Protection against oxidative aging
Typical dose
- Oral: 100-300 mg/day
- IV: Used in specialized clinics with provider-determined dosing
3. Glutathione & Vitamin C - IV or Oral
How they work
- Glutathione detoxifies cells, protects DNA and mitochondria
- Vitamin C supports collagen synthesis, immune health, and skin repair
Key benefits
- Reduced oxidative stress
- Enhanced detoxification
- Brighter skin and stronger immunity
Typical dose
- Glutathione: 250-1000 mg/day orally or IV therapy
- Vitamin C: 500-2000 mg/day orally or IV protocols as prescribed
4. NAC (N-Acetylcysteine)
NAC is a direct precursor to glutathione and plays a major role in cellular detoxification.
How it works
Key benefits
- Protection from oxidative stress
- Improved endurance and recovery
- Liver and detox pathway support
Typical dose
- 600-1800 mg/day, often divided into multiple doses
- Commonly paired with glycine (GlyNAC) for enhanced longevity benefits.
5. Creatine (Oral)
How it works
Key benefits
- Preserves muscle mass with age
- Improves strength and power
- Supports cognitive function and reduces fatigue
Typical dose
- 3-5 g/day (creatine monohydrate)
6. Vitamin D3 + K2 (MK-7)
How they work
- Vitamin D3 regulates immune function and calcium absorption
- Vitamin K2 (MK-7) ensures calcium is directed to bones, not arteries
Key benefits
- Strong bones and joints
- Cardiovascular protection
- Support for longevity-related pathways
Typical dose
- Vitamin D3: 1,000-2,000 IU/day (up to 4,000 IU if deficient)
- Vitamin K2 (MK-7): 100-200 mcg/day
7. Magnesium Glycinate
How it works
Key benefits
- Improved sleep quality
- Reduced stress and muscle tension
- Better metabolic and cellular function
Typical dose
- 200-400 mg elemental magnesium daily (glycinate form preferred)
8. Ashwagandha (Withania somnifera)
How it works
Key benefits
- Reduced stress and anxiety
- Improved sleep quality
- Enhanced endurance and recovery
Typical dose
- 300-600 mg/day of standardized extract
9. Moringa (Drumstick Tree Leaf)
How it works
Key benefits
- Immune and anti-inflammatory support
- Blood sugar and lipid balance
- Overall vitality and wellness
Typical dose
- 500-1,000 mg/day (extract form)
10. Resveratrol
How it works
Key benefits
- Cardiovascular protection
- Cellular and mitochondrial support
- Longevity signaling pathways
Typical dose
- 250-1000 mg/day
- Often taken with fat for better absorption.
Hackfitz Approach to Anti-Aging & Longevity
At Hackfitz, supplements are not used in isolation. True anti-aging requires a systems-based approach optimizing sleep, hormones, gut health, movement, recovery therapies, and nutrition together.
Longevity is built at the cellular level.
